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The Sacramento Bee offers advertising and marketing solutions to reach the people of Sacramento and Northern California. Whether you are promoting your business or want to get the word out on a yard sale, we have a solution for you. Please forward this error screen to sharedip-1666228125. The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved.
Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve efficacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects. The improved formulation of existing drugs is turning out to be lucrative business for pharmaceutical industry which is facing innovation deficit these days for new molecules.